Dosing and Administration
XHANCE is easy to use1
Please see Instructions for Use for detailed administration instructions.
To prime XHANCE for first use:

- Remove the cap and shake the device well
- Spray the device 7 times or until a fine mist is expelled
To use XHANCE2:

First, shake well. Then, using 1 or 2 hands, place your fingers on the indented grip BELOW the mouthpiece.
Gently insert the nosepiece into your nose to form a tight seal, then rotate to insert the flexible mouthpiece into your mouth while keeping the nosepiece deep in the nostril.

Aim the device upwards between your eyes.

Take a deep breath and exhale hard into the mouthpiece, as if blowing up a balloon.

Keep blowing as you press the bottle with your thumb, releasing the medicine deep into your nasal passages.
XHANCE is administered in each nostril twice daily
The recommended dosage is
1 spray per nostril (equal to 186 mcg) twice daily.
XHANCE is also approved for
2 sprays per nostril (equal to 372 mcg) twice daily.
The maximum total daily dosage should not exceed 2 sprays in each nostril twice daily (8 sprays total). For best results, patients should use XHANCE regularly, twice daily.
