The Mechanism of Delivery for XHANCE:
The Exhalation Delivery SystemTM (EDS®)
XHANCE targets delivery of fluticasone to where chronic sinusitis-related inflammation occurs1,2
Drug delivery of the EDS demonstrated through gamma scintigraphy.3
Gamma camera images after using a nasal spray without exhalation (left) and an earlier version of the EDS with exhalation (right). Both images are from the same healthy patient taken over a period of 2 minutes after administration with radiolabeled solution.
The clinical relevance of different drug delivery patterns has not been established.
A unique device changes intranasal drug delivery4,5
The EDS delivers the drug deeply throughout the sinuses and sinus drainage tracts.5
XHANCE is fragrance- and alcohol-free4
XHANCE is fragrance- and alcohol-free4
Dynamic mechanism during delivery3,5
Closed palate: Exhaling against resistance elevates the soft palate
Positive pressure: Widens entry passages to facilitate air flow
Bidirectional flow: Exhaled air enters the device, becomes entrained with drug aerosols, enters the nostril, deposits the drug throughout the nasal labyrinth, and exits from the opposite nostril
Three key features of EDS3,4
Sealing nosepiece
The sealing nosepiece is specifically shaped to seal tightly in the nostril, act as a stent in the nasal valve, and allow for the transfer of pressure from the mouth into the nose3,4
Nonremovable
drug-filled vial
The nonremovable drug-filled vial also acts as the actuator, releasing a burst of medication when pressed3,4
Flexible mouthpiece
The flexible mouthpiece enables a broad range of patients to utilize the device while maintaining a seal in the nostril3,4
Sealing nosepiece
The sealing nosepiece is specifically shaped to seal tightly in the nostril, act as a stent in the nasal valve, and allow for the transfer of pressure from the mouth into the nose3,4
Flexible mouthpiece
The flexible mouthpiece enables a broad range of patients to utilize the device while maintaining a seal in the nostril3,4
Nonremovable drug-filled vial
The nonremovable drug-filled vial also acts as the actuator, releasing a burst of medication when pressed3,4
Watch the EDS in action
How EDS works3,5
Exhalation elevates the soft palate, creating a seal that separates the nasal cavity from the oropharynx.
Air then enters the nostril through the sealing nosepiece, helping expand narrow nasal passages.
Medication entrained in the breath is deposited high and deep, flowing around anatomical structures.
Air then escapes out the opposite nostril.
In a clinical trial questionnaire, most patients reported that XHANCE was easy to use5
“When I explain the anatomy of closing the soft palate for the benefit of bidirectional flow and minimization of medication run-off posteriorly, [my patients] get really excited.”
Allergist Thomas Murphy, MD
Paid consultant of Optinose
Explore More
See the results of the XHANCE clinical trials
Show your patients how to administer XHANCE